A Unique Mammalian Suspension Technology Enhances Scalable rAAV Production with Pro10 Cell Line

In the realm of gene therapy manufacturing, a new technology has emerged that promises to revolutionize the efficiency and scalability of recombinant adeno-associated virus (rAAV) production. The Pro10™ cell line, developed by Viralgen, is a proprietary mammalian suspension technology that allows for scalable and robust production of rAAVs. This cutting-edge technology has been fully characterized and licensed for gene therapy development by other biopharma companies.

The Pro10™ cells have been optimized for rAAV production and successfully scaled up to 2000L, demonstrating consistent and reproducible cell growth rates. They exhibit similar productivity in small and large-scale bioreactors and can produce different AAV serotypes. This versatile cell line plays a crucial role in Viralgen’s platform process for manufacturing AAV vectors, which has been vital in producing groundbreaking gene therapies.

One of the key benefits of the Pro10™ cell line is its ability to reduce process development time and costs. This innovative technology offers a solution to the challenges faced in large-scale production of AAV vectors, making it an attractive option for biopharma companies looking to streamline their manufacturing processes. The PDF document provides a detailed description of the HEK293 derived animal component-free suspension Pro10™ cell line, highlighting its potential as a promising advancement in the field of gene therapy manufacturing.

Overall, the Pro10™ cell line represents an exciting new development in gene therapy manufacturing, offering a scalable and efficient solution to the challenges faced by biopharma companies looking to produce rAAVs on a large scale. With its ability to reduce process development time and costs while maintaining consistent productivity across different serotypes and scales, this innovative technology is poised to transform the field of gene therapy manufacturing for years to come.

By Sophia Gonzalez

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